Sunday, November 19, 2006

Nintendo has released its newest video game console in North America. Known as the Wii, the system and games have an MSRP of US$249.99 and US$49.99 respectively. The North American release is to be followed by the December 2nd launch in Japan and the December 8th launch in Europe.

Launched officially at midnight, more than a thousand people gathered in New York’s Time Square to be among the first to buy one of the Wii. In contrast to the crowds that have challenged crowd control officials over the last two days in connection with the launch of Sony’s Playstation 3, the Wii crowds have been much calmer. Many observers attribute this to the fact that Nintendo had more than ten times as many Wii consoles available on launching day than Sony did for their PS3 that had been hounded by part shortages in manufacturing right up to the day of launch.

Nintendo of America president Reggie Fils-Aime said that several tough choices had been made in the design of the Wii. The company decided to develop a new way of playing games with revolutionary controllers instead of following the PS3 and the Xbox down the road of stunning graphic and multimedia options. This produced a console with a much talked-about sensor/controller design and the lowest price point of the three major consoles. While not having a DVD player or high-definition TV capabilities, the Wii retails for about $250 while its competitors the Xbox 360 and PS3 retail for about $400 and $600 respectively.

While the Wii will launch with several games available, one of its advertised advantages is that the new console is largely compatible with older games made for the GameCube, giving the new console an instant and extensive launching library. A GameCube controller will be needed to play GameCube games with the Wii. Several hardware items that GameCube games may be expecting, such as the modem or broadband adapter or the GameBoy player are not supported on the Wii.

Across the country in Los Angeles about 500 people were waiting for the doors to open at Universal City Walk’s Game Stop store. Fearing that the Wii introduction might be as contentious as the PS3 debut just a few days ago, the store handed out numbered wristbands to the throng. No problems were reported.

Sunday, January 10, 2010

British Prime Minister Gordon Brown said on Saturday that the UK’s natural gas reserves will not run out in spite of record demand. This spike in demand is caused by the recent cold weather.File:Latenight-1.jpg

A supplier, National Grid, issued two “balancing alerts”, which mean a possible supply shortfall, which were promptly lifted. A spokeswoman for the company said that there was a possible shortfall of 35 million cubic metres (1.2 billion cubic feet). This third balancing alert is expected to last for the next few days, and is said not to be due to the cold weather – which is expected to continue for at least a week – but due to problems in Norwegian gas fields.

Another staple related to the cold snap, rock salt, is feared in short supply. The Automobile Association reports that supplies have been reduced by 250,000 tonnes over the last ten years. Local governments pledged to conserve supplies through a 25% reduction in the amount used; 12,000 tonnes of white salt have been redirected for use on roads.

Non-profits have asked that the allowance for gas money be temporarily raised for pensioners. The Red Cross reports that it is having the highest volume of aid being given out in nearly 30 years.

The cold snap has caused at least two further deaths, a 90-year-old woman who had frozen to death in her garden in Barnsley, and a 42-year-old who was found frozen in Newcastle, taking the total to 26.

Friday, September 1, 2006

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.

Monday, July 9, 2007

Tournament favourites and debutants Australia have drawn 1-1 with a skillful Oman in the second match in Group A of the 2007 AFC Asian Cup.

Oman shocked the Socceroos when they scored on thirty-two minutes, after some enterprising play on their left-hand flank. A ball cut back made its’ way through the Australian defence to Omani striker Badar Mubarak, who slotted the ball low into the left-hand corner of the goal.

Oman very nearly had a second goal on three separate occasions in the second half. They were only denied by three world-class saves by Australian goalkeeper Mark Schwarzer, including a low save from a driving volley by Ahmed Mubarak, a reflex save to stop a point-blank header in the seventieth minute, and then another low-down save minutes later from Fawi Bashir’s driving shot.

A heavy downpour began ten minutes prior to the final whistle, and it appeared to reinvigorate Australia. They pressed forward in numbers, and were rewarded in injury time with a goal to Everton midfielder Tim Cahill, after a low volley by Marco Bresciano was well-saved by Omani keeper Suleiman Al Mazroui.

Cahill achieved the remarkable double of scoring both Australia’s first Asian Cup and World Cup goals, after he scored in the eighty-third minute of their match against Japan at the 2006 FIFA World Cup. He and John Aloisi capped off the comeback by scoring twice late to defeat Japan 3-1.

The Australian players were visibly frustrated by Oman’s play-acting tactics, which saw the stretcher used four times in the first half alone. British match commentator Simon Hill described the tactics as “a blight to the game” and “absolutely rubbish”, the latter in relation to one incident where no contact was made whatsoever. When queried about it after the game, Arnold said cynically “welcome to Asia”.

The Australians were flat and their defending was poor, said coach Graham Arnold at the post-match media conference. He also commented on goalkeeper Schwarzer’s three fantastic saves, saying “Mark Schwarzer’s got us out of jail. Schwarzer’s made two unbelievable saves, otherwise it’s 2-0 and all over”.

The draw leaves all four Group A teams equal on the table on one point, with one goal for and one against, following Iraq 1-1 draw with hosts Thailand yesterday.

In the other game played yesterday (UTC), co-hosts Vietnam caused a major shock by defeating United Arab Emirates in their Group B fixture.

The Emirates are the current Gulf Cup champions, and the hosts were expected to struggle to win this match, or progress from Group B which includes two-time Asian champions Japan and Asian Games gold medallists Qatar. Vietnam is playing at Asian Cup level for the first time in nearly half a century.

UAE had the better of the chances in an otherwise-even first half, with the best Faisal Khalil‘s shot in the thirtieth minute, which was well-saved by Vietnamese goalkeeper Duong Hong Son who managed to turn the ball around the post for a corner.

However, they scored two second half goals to take the three points from the My Dinh National Stadium. On sixty-three minutes, a counter-attack from the half-way line involving three Vietnamese players resulted in defender Huynh Quang Thanh putting the ball in the back of the net.

Vietnamese player of the year Le Cong Vinh made it 2-0 nine minutes later when he chased down a long ball and calmly lobbed it over Emirates goalkeeper Majed Nasser, who had come off his line to try and avert the danger.

Bruno Metsu, coach of the United Arab Emirates, substituted players and launched an all-out attack to try and salvage something, but failed to find the goals he needed.

Thursday, December 18, 2008

A team of eight transplant surgeons in Cleveland Clinic in Ohio, USA, led by reconstructive surgeon Dr. Maria Siemionow, age 58, have successfully performed the first almost total face transplant in the US, and the fourth globally, on a woman so horribly disfigured due to trauma, that cost her an eye. Two weeks ago Dr. Siemionow, in a 23-hour marathon surgery, replaced 80 percent of her face, by transplanting or grafting bone, nerve, blood vessels, muscles and skin harvested from a female donor’s cadaver.

The Clinic surgeons, in Wednesday’s news conference, described the details of the transplant but upon request, the team did not publish her name, age and cause of injury nor the donor’s identity. The patient’s family desired the reason for her transplant to remain confidential. The Los Angeles Times reported that the patient “had no upper jaw, nose, cheeks or lower eyelids and was unable to eat, talk, smile, smell or breathe on her own.” The clinic’s dermatology and plastic surgery chair, Francis Papay, described the nine hours phase of the procedure: “We transferred the skin, all the facial muscles in the upper face and mid-face, the upper lip, all of the nose, most of the sinuses around the nose, the upper jaw including the teeth, the facial nerve.” Thereafter, another team spent three hours sewing the woman’s blood vessels to that of the donor’s face to restore blood circulation, making the graft a success.

The New York Times reported that “three partial face transplants have been performed since 2005, two in France and one in China, all using facial tissue from a dead donor with permission from their families.” “Only the forehead, upper eyelids, lower lip, lower teeth and jaw are hers, the rest of her face comes from a cadaver; she could not eat on her own or breathe without a hole in her windpipe. About 77 square inches of tissue were transplanted from the donor,” it further described the details of the medical marvel. The patient, however, must take lifetime immunosuppressive drugs, also called antirejection drugs, which do not guarantee success. The transplant team said that in case of failure, it would replace the part with a skin graft taken from her own body.

Dr. Bohdan Pomahac, a Brigham and Women’s Hospital surgeon praised the recent medical development. “There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Leading bioethicist Arthur Caplan of the University of Pennsylvania withheld judgment on the Cleveland transplant amid grave concerns on the post-operation results. “The biggest ethical problem is dealing with failure — if your face rejects. It would be a living hell. If your face is falling off and you can’t eat and you can’t breathe and you’re suffering in a terrible manner that can’t be reversed, you need to put on the table assistance in dying. There are patients who can benefit tremendously from this. It’s great that it happened,” he said.

Dr Alex Clarke, of the Royal Free Hospital had praised the Clinic for its contribution to medicine. “It is a real step forward for people who have severe disfigurement and this operation has been done by a team who have really prepared and worked towards this for a number of years. These transplants have proven that the technical difficulties can be overcome and psychologically the patients are doing well. They have all have reacted positively and have begun to do things they were not able to before. All the things people thought were barriers to this kind of operations have been overcome,” she said.

The first partial face transplant surgery on a living human was performed on Isabelle Dinoire on November 27 2005, when she was 38, by Professor Bernard Devauchelle, assisted by Professor Jean-Michel Dubernard in Amiens, France. Her Labrador dog mauled her in May 2005. A triangle of face tissue including the nose and mouth was taken from a brain-dead female donor and grafted onto the patient. Scientists elsewhere have performed scalp and ear transplants. However, the claim is the first for a mouth and nose transplant. Experts say the mouth and nose are the most difficult parts of the face to transplant.

In 2004, the same Cleveland Clinic, became the first institution to approve this surgery and test it on cadavers. In October 2006, surgeon Peter Butler at London‘s Royal Free Hospital in the UK was given permission by the NHS ethics board to carry out a full face transplant. His team will select four adult patients (children cannot be selected due to concerns over consent), with operations being carried out at six month intervals. In March 2008, the treatment of 30-year-old neurofibromatosis victim Pascal Coler of France ended after having received what his doctors call the worlds first successful full face transplant.

Ethical concerns, psychological impact, problems relating to immunosuppression and consequences of technical failure have prevented teams from performing face transplant operations in the past, even though it has been technically possible to carry out such procedures for years.

Mr Iain Hutchison, of Barts and the London Hospital, warned of several problems with face transplants, such as blood vessels in the donated tissue clotting and immunosuppressants failing or increasing the patient’s risk of cancer. He also pointed out ethical issues with the fact that the procedure requires a “beating heart donor”. The transplant is carried out while the donor is brain dead, but still alive by use of a ventilator.

According to Stephen Wigmore, chair of British Transplantation Society’s ethics committee, it is unknown to what extent facial expressions will function in the long term. He said that it is not certain whether a patient could be left worse off in the case of a face transplant failing.

Mr Michael Earley, a member of the Royal College of Surgeon‘s facial transplantation working party, commented that if successful, the transplant would be “a major breakthrough in facial reconstruction” and “a major step forward for the facially disfigured.”

In Wednesday’s conference, Siemionow said “we know that there are so many patients there in their homes where they are hiding from society because they are afraid to walk to the grocery stores, they are afraid to go the the street.” “Our patient was called names and was humiliated. We very much hope that for this very special group of patients there is a hope that someday they will be able to go comfortably from their houses and enjoy the things we take for granted,” she added.

In response to the medical breakthrough, a British medical group led by Royal Free Hospital’s lead surgeon Dr Peter Butler, said they will finish the world’s first full face transplant within a year. “We hope to make an announcement about a full-face operation in the next 12 months. This latest operation shows how facial transplantation can help a particular group of the most severely facially injured people. These are people who would otherwise live a terrible twilight life, shut away from public gaze,” he said.

Tuesday, August 16, 2011

Alfred Hsing, a US martial artist with Chinese origins, besides having a long history of martial arts training in various styles, such as traditional kung fu, tae kwon do and karate, considers wushu – an athletic sport based on Chinese martial arts – as a form of art that pushes one’s physical limits and stimulates the mind at the same time. After having won the gold medal at the 10th World Wushu Championships, he became international movie star Jet Li’s personal assistant and went on to do stunts, action choreography, and land roles in movies.

Hungarian Wikinews contributor Teemeah has interviewed Alfred Hsing about his views on martial arts, life and Wikipedia.

Wednesday, March 31, 2010

The World Health Organization (WHO) is a program of the United Nations and a global authority on human health. In an interview with Wikinews, the WHO tells about the current H1N1 pandemic.

The organization’s 93rd update as of March 26, 2010 states 213 countries, territories, and other communities have laboratory-confirmed cases and there have been at least 16,931 confirmed deaths, including 4,653 deaths in Europe and 7,673 in the Americas.

Wikinews reporter Mike Morales talks with Karen Mah, a media relations representative for the WHO, and asks her several questions.